Discovery of novel 6-hydroxybenzothiazole urea derivatives as dual Dyrk1A/α-synuclein aggregation inhibitors with neuroprotective effects

Monitoring Drug Target Engagement in Cells and Tissues Using the Cellular Thermal Shift Assay

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Medicine, Oncology, Pharmacology +17

High throughput artificial membrane permeability assay for blood–brain barrier

Li Di, Edward H. Kerns, Kristi Fan et al. · European Journal of Medicinal Chemistry · 2003 · 1.1K citations

Pharmacy, Biomedical Engineering, Neuroscience +11

A natural product inhibits the initiation of α-synuclein aggregation and suppresses its toxicity

Michele Perni, Céline Galvagnion, Alexander S. Maltsev et al. · Proceedings of the National Academy of Sciences · 2017 · 299 citations · Full text

Life Sciences, Biochemistry, Neuroscience +17

Harmine specifically inhibits protein kinase DYRK1A and interferes with neurite formation

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Medicine, Medicinal Chemistry, Pharmacology +15

DYRK1A-mediated Hyperphosphorylation of Tau

Soo‐Ryoon Ryoo, Hey Kyeong Jeong, Chinzorig Radnaabazar et al. · Journal of Biological Chemistry · 2007 · 271 citations · Full text

Life Sciences, Molecular Biology, Neuroscience +13