Concepedia

Aggregation Inhibitors

Aggregation Inhibitor is a biochemical agent that belongs to the class of molecular modulators designed to prevent or reduce the misfolding and subsequent self-association of proteins into insoluble aggregates, thereby distinguishing itself by specifically targeting the nucleation, elongation, or secondary propagation phases of amyloid or amorphous aggregate formation.

574

Publications

29.8K

Citations

3K

Authors

899

Institutions

Publications per year

2017–2026

210

Variants

Aggregation Inhibitor

Parents

Publications

574

Small Molecule Inhibitors of Aggregation Indicate That Amyloid β Oligomerization and Fibrillization Pathways Are Independent and Distinct

Mihaela Necula, Rakez Kayed, Saskia Milton et al. · Journal of Biological Chemistry · 2007 · 680 citations · Full text

, , +17

A Specific Mechanism of Nonspecific Inhibition

Susan L. McGovern, Brian T. Helfand, Brian Y. Feng et al. · Journal of Medicinal Chemistry · 2003 · 605 citations · Full text

, , +17

Selective inhibition of Alzheimer disease-like tau aggregation by phenothiazines.

Claude M. Wischik, Patricia C. Edwards, Robert Lai et al. · Proceedings of the National Academy of Sciences · 1996 · 541 citations

, , +17

Identification and Prediction of Promiscuous Aggregating Inhibitors among Known Drugs

James A. Seidler, Susan L. McGovern, Thompson N. Doman et al. · Journal of Medicinal Chemistry · 2003 · 480 citations · Full text

, , +14

Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease

Jens A. Wagner, Sergey Ryazanov, Andrei Leonov et al. · Acta Neuropathologica · 2013 · 456 citations · Full text

, , +17

1–5 of 574

Authors

3K

  1. ES
    Eddy Sotelo

    Universidade de Santiago de Compostela, Spain

    10 publications · 275 citations

    10

    h-index

  2. SV
    Salvador Ventura

    Universitat Autònoma de Barcelona, Spain

    8 publications · 300 citations

    8

    h-index

  3. ER
    Enrique Raviña

    Universidade de Santiago de Compostela, Spain

    7 publications · 219 citations

    7

    h-index

  4. KK
    Kiyomi Kikugawa

    Tokyo University of Pharmacy and Life Sciences, Japan

    7 publications · 179 citations

    7

    h-index

  5. PP
    Praveen P. N. Rao

    University of Waterloo, Canada

    7 publications · 298 citations

    7

    h-index

1–5 of 3K

Institutions

899

  1. University of California, San Francisco

    San Francisco, United States

    10 h-index

    32 publications

    9.1K citations

  2. Universitat de Barcelona

    Barcelona, Spain

    10 h-index

    33 publications

    1.5K citations

  3. University of Waterloo

    Waterloo, Canada

    9 h-index

    27 publications

    879 citations

  4. Universidade de Santiago de Compostela

    Santiago de Compostela, Spain

    9 h-index

    40 publications

    1.1K citations

  5. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    40 publications

    1.4K citations

  6. Kyoto University

    Kyoto, Japan

    8 h-index

    32 publications

    1.7K citations

  7. Universitat Autònoma de Barcelona

    Cerdanyola del Vallès, Spain

    8 h-index

    29 publications

    1.2K citations

  8. Sun Yat-sen University

    Guangzhou, China

    8 h-index

    42 publications

    1.9K citations

1–8 of 899

Venues

  1. Journal of Medicinal Chemistry

    23 publications · 2.4K citations

    20

    h-index

  2. Proceedings of the National Academy of Sciences

    PNAS · 17 publications · 3K citations

    17

    h-index

  3. Chemical and Pharmaceutical Bulletin

    24 publications · 686 citations

    17

    h-index

  4. European Journal of Medicinal Chemistry

    18 publications · 822 citations

    16

    h-index

  5. ACS Chemical Neuroscience

    20 publications · 638 citations

    15

    h-index

1–5