Concepedia

Discovery of Reldesemtiv, a Fast Skeletal Muscle Troponin Activator for the Treatment of Impaired Muscle Function

Scott E. Collibee, Gustave Bergnes, Chih-Yuan Chuang, Luke Ashcraft, Jeffrey Gardina, Marc Garard, Chris R. Jamison, Kevin Lu, Pu‐Ping Lu, Alexander R. Muci,

Journal of Medicinal Chemistry · 2021 · 25 citations · 18 references

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Concepts

Abstract

muscle activation potency compared to the first-generation FSTA, tirasemtiv. Reldesemtiv demonstrated increased muscle force generation in a phase 1 clinical trial and is currently being evaluated in clinical trials for the treatment of amyotrophic lateral sclerosis.

References

18

Manuscript Preparation

Obesity Surgery · 1997 · 3.9K citations

The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod

Ben Jones, David J. Roberts · Journal of Pharmacy and Pharmacology · 1968 · 587 citations

, , +10

Contraction-induced injury: recovery of skeletal muscles in young and old mice

Susan V. Brooks, John A. Faulkner · American Journal of Physiology-Cell Physiology · 1990 · 244 citations

, , +15

An Analysis of the Binding Efficiencies of Drugs and Their Leads in Successful Drug Discovery Programs

Emanuele Perola · Journal of Medicinal Chemistry · 2010 · 191 citations

, , +16

Effects of high- and low-velocity resistance training on the contractile properties of skeletal muscle fibers from young and older humans

Dennis R. Claflin, Lisa M. Larkin, Paul S. Cederna et al. · Journal of Applied Physiology · 2011 · 141 citations · Full text

, , +17