The quantitative measurement of motor inco-ordination in naive mice using an accelerating rotarod

Abstract

Abstract A simple modification of the standard rotarod apparatus is described which eliminates the necessity of time-consuming training and consequently gives a truer measure of motor co-ordination since any effects on memory are avoided. The sensitivity and reproducibility of the procedure are much greater than those obtained with constant speed rotarods and less animals are required to obtain statistically significant results.