Concepedia

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor

Rong Hu, Wanli Wang, Ying-Yue Yang, Xia-Tong Hu, Qiwei Wang, Weiqiong Zuo, Ying Xu, Qiang Feng, Ningyu Wang

European Journal of Medicinal Chemistry · 2021 · 47 citations · 38 references

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References

38

An inhibitor of NEDD8-activating enzyme as a new approach to treat cancer

Teresa A. Soucy, Peter G. Smith, Michael A. Milhollen et al. · Nature · 2009 · 2K citations

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RNAi screen identifies Brd4 as a therapeutic target in acute myeloid leukaemia

Johannes Zuber, Junwei Shi, Eric Wang et al. · Nature · 2011 · 1.9K citations

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Histone Recognition and Large-Scale Structural Analysis of the Human Bromodomain Family

P. Filippakopoulos, S. Picaud, Maria Mangos et al. · Cell · 2012 · 1.8K citations · Full text

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Phthalimide conjugation as a strategy for in vivo target protein degradation

Georg E. Winter, Dennis L. Buckley, Joshiawa Paulk et al. · Science · 2015 · 1.7K citations

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Inhibition of BET recruitment to chromatin as an effective treatment for MLL-fusion leukaemia

Mark A. Dawson, Rab K. Prinjha, Antje Dittmann et al. · Nature · 2011 · 1.5K citations · Full text

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