Nifuroxazide exerts potent anti-tumor and anti-metastasis activity in melanoma

Yongxia Zhu, Tinghong Ye, Xi Yu, +16

Scientific Reports

Synthesis and structure–activity relationships evaluation of benzothiazinone derivatives as potential anti-tubercular agents

Chao Gao, Tinghong Ye, Ningyu Wang, +10

Bioorganic & Medicinal Chemistry Letters

Potential Anti-tubercular AgentsBenzothiazinone DerivativesMedicinePharmacological AgentPharmacotherapy +4

Discovery and structure–activity relationships study of novel thieno[2,3-b]pyridine analogues as hepatitis C virus inhibitors

Ningyu Wang, Weiqiong Zuo, Ying Xu, +9

Bioorganic & Medicinal Chemistry Letters

MedicineAntiviral Drug DevelopmentRational Drug DesignStructure–activity Relationships StudyChemistry +4

Benzothiazinethione is a potent preclinical candidate for the treatment of drug-resistant tuberculosis

Chao Gao, Cuiting Peng, Xinyu You, +10

Scientific Reports

Identification of a selective BRD4 PROTAC with potent antiproliferative effects in AR-positive prostate cancer based on a dual BET/PLK1 inhibitor

Rong Hu, Wanli Wang, Ying-Yue Yang, +6

European Journal of Medicinal Chemistry

UrologyOncologyGenitourinary CancerMedicineSelective Brd4 Protac +6

Synthesis and antitubercular evaluation of 4-carbonyl piperazine substituted 1,3-benzothiazin-4-one derivatives

Cuiting Peng, Chao Gao, Ningyu Wang, +10

Bioorganic & Medicinal Chemistry Letters

Medicinal Chemistry4-Carbonyl PiperazineDerivativesHeterocyclicDerivative (Chemistry) +6

Discovery of Imidazo[2,1-<i>b</i>]thiazole HCV NS4B Inhibitors Exhibiting Synergistic Effect with Other Direct-Acting Antiviral Agents

Ningyu Wang, Ying Xu, Weiqiong Zuo, +17

Journal of Medicinal Chemistry

Molecular PharmacologyAntimicrobial Drug DiscoveryHcv InfectionAntiviral CompoundMedicine +12

Novel selective TOPK inhibitor SKLB-C05 inhibits colorectal carcinoma growth and metastasis

Tiantao Gao, Quanfang Hu, Xi Hu, +11

Cancer Letters

OncologyMedicineColorectal CancerPathologyCancer Biology +4

Repurposing of the anti-helminthic drug niclosamide to treat melanoma and pulmonary metastasis via the STAT3 signaling pathway

Yongxia Zhu, Weiqiong Zuo, Lijuan Chen, +10

Biochemical Pharmacology

InflammationAnti-helminthic Drug NiclosamideNovel TherapyMedicineImmunology +6

Design, synthesis, and biological evaluation of 4,5-dihydro-[1,2,4]triazolo[4,3-f]pteridine derivatives as novel dual-PLK1/BRD4 inhibitors

Ningyu Wang, Ying Xu, Kun-Jie Xiao, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryDerivative (Chemistry)BiochemistryMedicine +9