mSphere · 2021 · 56 citations · 32 references
MedicineMolecular BiologyOncologyCarcinogenesisMolecular OncologyOncogenesCancer Cell SignalingGastric CancerGastric DiseasesOncogenic Signaling PathwaysOncogenic VirusesViral CarcinogenesisEpstein-barr Virus OncogenesisEpstein-barr Virus-associated CarcinogenesisHelicobacter Pylori InfectionHelicobacter Pylori PathogenesisHelicobacter Pylori-associated Gastric CarcinogenesisOncogenic TransformationPathogen-induced Gene ExpressionPathogenesis-associated Gene Expression
In the present study, we evaluated the synergistic effects of EBV and H. pylori infection on gastric epithelial cells in various coinfection models. These coinfection models were among the first to depict the exposures of gastric epithelial cells to EBV followed by H. pylori; however, coinfection models exist that narrated the scenario upon exposure to H. pylori followed by that to EBV. We determined that a coinfection by EBV and H. pylori enhanced the expression of oncogenic protein gankyrin. The interplay between EBV and H. pylori promoted the oncogenic properties of AGS cells like elevated focus formation, cell migration, and cell proliferation through gankyrin. EBV and H. pylori mediated an enhanced expression of gankyrin, which further dysregulated cancer-associated genes such as cell migratory, tumor suppressor, DNA damage response, and proapoptotic genes.
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Gankyrin: a new oncoprotein and regulator of pRb and p53
Simon Dawson, Hiroaki Higashitsuji, Anthony J. Wilkinson et al. · Trends in Cell Biology · 2006 · 89 citations