Reduced stability of retinoblastoma protein by gankyrin, an oncogenic ankyrin-repeat protein overexpressed in hepatomas

Hiroaki Higashitsuji, Katsuhiko Itoh, Toshikazu Nagao, +6

Nature Medicine

Tumor BiologyOncogenic Ankyrin-repeat ProteinRetinoblastoma ProteinPathologyReduced Stability +5

The oncoprotein gankyrin binds to MDM2/HDM2, enhancing ubiquitylation and degradation of p53

Hiroaki Higashitsuji, Hisako Higashitsuji, Katsuhiko Itoh, +8

Cancer Cell

Tumor BiologyOncoprotein GankyrinMedicineMolecular BiologyProtein Degradation +4

Increased Transcript Level of RBM3, a Member of the Glycine-Rich RNA-Binding Protein Family, in Human Cells in Response to Cold Stress

Shozo Danno, Hiroyuki Nishiyama, Hiroaki Higashitsuji, +5

Biochemical and Biophysical Research Communications

Cold StressHuman CellsMedicineNatural SciencesRna Biology +7

Cloning and characterization of human CIRP (cold-inducible RNA-binding protein) cDNA and chromosomal assignment of the gene

Hiroyuki Nishiyama, Hiroaki Higashitsuji, Hiromichi Yokoi, +4

Gene

ChromatinChromosomal AssignmentCold-inducible Rna-binding ProteinGeneticsNatural Sciences +10

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

Simon Dawson, Sébastien Apcher, Maureen Mee, +6

Journal of Biological Chemistry

Cirp protects against tumor necrosis factor-α-induced apoptosis via activation of extracellular signal-regulated kinase

Toshiharu Sakurai, Katsuhiko Itoh, Hiroaki Higashitsuji, +7

Biochimica et Biophysica Acta (BBA) - Molecular Cell Research

InflammationSignal TransductionSignaling PathwayApoptosisImmune Regulation +9

MAGE-A4 Interacts with the Liver Oncoprotein Gankyrin and Suppresses Its Tumorigenic Activity

Toshikazu Nagao, Hiroaki Higashitsuji, Kohsuke Nonoguchi, +5

Journal of Biological Chemistry

Effects of ischemia and H2O2 on the cold stress protein CIRP expression in rat neuronal cells

Jing-Hui Xue, Kohsuke Nonoguchi, Manabu Fukumoto, +5

Free Radical Biology and Medicine

InflammationReductive StressMolecular PhysiologySignal TransductionPhysiology +11

The Crystal Structure of Gankyrin, an Oncoprotein Found in Complexes with Cyclin-dependent Kinase 4, a 19 S Proteasomal ATPase Regulator, and the Tumor Suppressors Rb and p53

Szymon Krzywda, A.M. Brzozowski, Hiroaki Higashitsuji, +5

Journal of Biological Chemistry

Gankyrin: a new oncoprotein and regulator of pRb and p53

Simon Dawson, Hiroaki Higashitsuji, Anthony J. Wilkinson, +2

Trends in Cell Biology

Signaling PathwayCell RegulationOncogenic AgentMedicineMolecular Biology +7