Depletion of 26S Proteasomes in Mouse Brain Neurons Causes Neurodegeneration and Lewy-Like Inclusions Resembling Human Pale Bodies

Lynn Bedford, David Hay, Anny Devoy, +15

Journal of Neuroscience

Gankyrin Is an Ankyrin-repeat Oncoprotein That Interacts with CDK4 Kinase and the S6 ATPase of the 26 S Proteasome

Simon Dawson, Sébastien Apcher, Maureen Mee, +6

Journal of Biological Chemistry

The LIMD1 protein bridges an association between the prolyl hydroxylases and VHL to repress HIF-1 activity

Daniel E. Foxler, Katherine S. Bridge, Victoria James, +11

Nature Cell Biology

Reductive StressProtein FunctionBiochemistryNatural SciencesMolecular Biology +6

TLR2 Stimulation Regulates the Balance between Regulatory T Cell and Th17 Function: A Novel Mechanism of Reduced Regulatory T Cell Function in Multiple Sclerosis

Mukanthu H. Nyirenda, Elena Morandi, Uwe Vinkemeier, +10

The Journal of Immunology

STAT2 Is a Pervasive Cytokine Regulator due to Its Inhibition of STAT1 in Multiple Signaling Pathways

Johnathan Ho, Christin Pelzel, Andreas Begitt, +4

PLoS Biology

Inflammatory Lung DiseaseImmunologyImmune RegulationImmunologic MechanismInnate Immunity +24

The UPS and autophagy in chronic neurodegenerative disease: Six of one and half a dozen of the other—Or not?

Lynn Bedford, Simon Paine, Nooshin Rezvani, +3

Autophagy

Synthetic, structural and biological studies of the ubiquitin system: synthesis and crystal structure of an analogue containing unnatural amino acids

S G Love, Tom W. Muir, R. Ramage, +8

Biochemical Journal

Combinatorial ChemistryCrystal StructureProtein AssemblyBiomolecular Structure PredictionMolecular Biology +15

Proteasomal degradation of the metabotropic glutamate receptor 1α is mediated by Homer‐3 via the proteasomal S8 ATPase

Khosrow Rezvani, Kelli Baalman, Yanfen Teng, +5

Journal of Neurochemistry

S8 AtpaseSynaptic TransmissionProteasomeProteasome Regulatory SubunitsSynaptic Signaling +19

Human feeder cell line for derivation and culture of hESc/hiPSc

Tristan R. McKay, María V. Camarasa, Banu İskender, +10

Stem Cell Research

Human CellDevelopmental BiologyCell CultureStem Cell ResearchTissue Culture +3

Crystallization of gankyrin, an oncoprotein that interacts with CDK4 and the S6b (rpt3) ATPase of the 19S regulator of the 26S proteasome

Szymon Krzywda, A.M. Brzozowski, Roisin Al-Safty, +7

Acta Crystallographica Section D Biological Crystallography