Functional recovery by colon organoid transplantation in a mouse model of radiation proctitis

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 7.2K citations

Life Sciences, Cell Biology, Developmental Biology +14

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.7K citations

Life Sciences, Cell Biology, Genetics +16

Long-term Expansion of Epithelial Organoids From Human Colon, Adenoma, Adenocarcinoma, and Barrett's Epithelium

Toshiro Sato, Daniel E. Stange, Marc Ferrante et al. · Gastroenterology · 2011 · 3.8K citations · Full text

Medicine, Cell Biology, Pathology +14

Functional engraftment of colon epithelium expanded in vitro from a single adult Lgr5+ stem cell

Shiro Yui, Tetsuya Nakamura, Toshiro Sato et al. · Nature Medicine · 2012 · 800 citations

Life Sciences, Cell Biology, Developmental Biology +16

In vitro expansion and genetic modification of gastrointestinal stem cells in spheroid culture

Hiroyuki Miyoshi, Thaddeus S. Stappenbeck · Nature Protocols · 2013 · 793 citations · Full text

Life Sciences, Biotechnology, Cell Biology +17