Cytoplasmic DNA sensing by KU complex in aged CD4+ T cell potentiates T cell activation and aging-related autoimmune inflammation

Cyclic GMP-AMP Synthase Is a Cytosolic DNA Sensor That Activates the Type I Interferon Pathway

Lijun Sun, Jiaxi Wu, Fenghe Du et al. · Science · 2012 · 4.8K citations

Life Sciences, Immunology, Molecular Biology +16

Rapamycin fed late in life extends lifespan in genetically heterogeneous mice

Randy Strong, Z. Dave Sharp, James F. Nelson et al. · Nature · 2009 · 3.7K citations · Full text

Education, Genetics, Nutrition +15

Caloric Restriction Delays Disease Onset and Mortality in Rhesus Monkeys

Ricki J. Colman, Rozalyn M. Anderson, Sterling C. Johnson et al. · Science · 2009 · 2.3K citations · Full text

Education, Nutrition, Nutritional Sciences +17

Structure of the Ku heterodimer bound to DNA and its implications for double-strand break repair

John R. Walker, Richard A. Corpina, Jonathan M. Goldberg · Nature · 2001 · 1.2K citations

Life Sciences, Biology, Molecular Biology +14

Cyclic GMP-AMP Synthase Is an Innate Immune Sensor of HIV and Other Retroviruses

Daxing Gao, Jiaxi Wu, You-Tong Wu et al. · Science · 2013 · 988 citations

Life Sciences, Immunology, Microbiology +15