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Synthesis and structure-activity relationships of pyrimidine derivatives as potent and orally active FGFR3 inhibitors with both increased systemic exposure and enhanced in vitro potency

Medicinal ChemistryPharmaceutical ScienceMedicineSystemic ExposurePharmacological AgentActive Fgfr3 InhibitorsPharmacotherapyDrug DevelopmentPharmacologyPharmaceutical ChemistryBiomolecular EngineeringDrug DiscoveryPyrimidine Derivatives