Concepedia

Targeting CD38-dependent NAD+ metabolism to mitigate multiple organ fibrosis

Bo Shi, Wenxia Wang, Benjamin D. Korman, Kai Li, Qianqian Wang, Jun Wei, Swarna Bale, Roberta Gonçalves Marangoni, Swati Bhattacharyya, Stephen D. Miller,

iScience · 2020 · 62 citations · 45 references

DOIFull text

Open access

Concepts

Abstract

homeostasis as a fundamental mechanism driving fibrosis in SSc, suggesting that CD38 might represent a novel therapeutic target.

References

45

Declining NAD+ Induces a Pseudohypoxic State Disrupting Nuclear-Mitochondrial Communication during Aging

Ana P. Gomes, Nathan L. Price, Alvin J. Y. Ling et al. · Cell · 2013 · 1.5K citations · Full text

, , +12

Separation of functional subsets of human T cells by a monoclonal antibody.

Ellis L. Reinherz, Patrick C. Kung, Gideon Goldstein et al. · Proceedings of the National Academy of Sciences · 1979 · 1.1K citations · Full text

, , +16

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Juliana Camacho-Pereira, Mariana G. Tarragó, Claudia C.S. Chini et al. · Cell Metabolism · 2016 · 867 citations · Full text

, , +16

Age Related Changes in NAD+ Metabolism Oxidative Stress and Sirt1 Activity in Wistar Rats

Nady Braidy, Gilles J. Guillemin, Hussein Mansour et al. · PLoS ONE · 2011 · 599 citations · Full text

, , +17

Age-Associated Changes In Oxidative Stress and NAD+ Metabolism In Human Tissue

Hassina Massudi, Ross Grant, Nady Braidy et al. · PLoS ONE · 2012 · 548 citations · Full text

, , +17