Mariana G. Tarragó

CD38 Dictates Age-Related NAD Decline and Mitochondrial Dysfunction through an SIRT3-Dependent Mechanism

Juliana Camacho-Pereira, Mariana G. Tarragó, Claudia C.S. Chini et al. · Cell Metabolism · 2016 · 830 citations · Full text

Age-related Nad Decline, Aging, Mitochondrial Function +10

A Potent and Specific CD38 Inhibitor Ameliorates Age-Related Metabolic Dysfunction by Reversing Tissue NAD+ Decline

Mariana G. Tarragó, Claudia C.S. Chini, Karina S. Kanamori et al. · Cell Metabolism · 2018 · 355 citations · Full text

Lifespan Extension, Metabolic Syndrome, Aging +12

CD38 ecto-enzyme in immune cells is induced during aging and regulates NAD+ and NMN levels

Claudia C.S. Chini, Thais Peclat, Gina M. Warner et al. · Nature Metabolism · 2020 · 306 citations · Full text

Inflammation, Immune Cells, Nmn Levels +11

The NADase CD38 is induced by factors secreted from senescent cells providing a potential link between senescence and age-related cellular NAD+ decline

Claudia C.S. Chini, Kelly A. Hogan, Gina M. Warner et al. · Biochemical and Biophysical Research Communications · 2019 · 128 citations · Full text

CD38 inhibitor 78c increases mice lifespan and healthspan in a model of chronological aging

Thais Peclat, Katie L. Thompson, Gina M. Warner et al. · Aging Cell · 2022 · 44 citations · Full text