Myofibroblasts in Murine Cutaneous Fibrosis Originate From Adiponectin‐Positive Intradermal Progenitors

Roberta Gonçalves Marangoni, Benjamin D. Korman, Jun Wei, +6

Arthritis & Rheumatology

Canonical Wnt signaling induces skin fibrosis and subcutaneous lipoatrophy: A novel mouse model for scleroderma?

Jun Wei, Denisa S. Melichian, Kazuhiro Komura, +6

Arthritis & Rheumatism

PPARγ Downregulation by TGFß in Fibroblast and Impaired Expression and Function in Systemic Sclerosis: A Novel Mechanism for Progressive Fibrogenesis

Jun Wei, Asish K. Ghosh, Jennifer L. Sargent, +7

PLoS ONE

The adipokine adiponectin has potent anti-fibrotic effects mediated via adenosine monophosphate-activated protein kinase: novel target for fibrosis therapy

Feng Fang, Lei Liu, Yang Yang, +7

Arthritis Research & Therapy

p300 Is Elevated in Systemic Sclerosis and Its Expression Is Positively Regulated by TGF-β: Epigenetic Feed-Forward Amplification of Fibrosis

Asish K. Ghosh, Swati Bhattacharyya, Robert Lafyatis, +5

Journal of Investigative Dermatology

InflammationFibrosisAutoimmune DiseaseSystemic SclerodermaImmune Cell Development +9

SIRT3 is attenuated in systemic sclerosis skin and lungs, and its pharmacologic activation mitigates organ fibrosis

Kaname Akamata, Jun Wei, Mitra Bhattacharyya, +7

Oncotarget

Levels of adiponectin, a marker for PPAR-gamma activity, correlate with skin fibrosis in systemic sclerosis: potential utility as biomarker?

Katja Lakota, Jun Wei, Mary Carns, +5

Arthritis Research & Therapy

The Early Growth Response Gene Egr2 (Alias Krox20) Is a Novel Transcriptional Target of Transforming Growth Factor-β that Is Up-Regulated in Systemic Sclerosis and Mediates Profibrotic Responses

Feng Fang, Kohtaro Ooka, Swati Bhattachyya, +7

American Journal Of Pathology

Transcriptional RegulationTissue DevelopmentAutoimmune DiseaseSignaling PathwayCell Regulation +10

The JAK/STAT pathway is activated in systemic sclerosis and is effectively targeted by tofacitinib

Wenxia Wang, Swati Bhattacharyya, Roberta Gonçalves Marangoni, +5

Journal of Scleroderma and Related Disorders

The Histone Deacetylase Sirtuin 1 Is Reduced in Systemic Sclerosis and Abrogates Fibrotic Responses by Targeting Transforming Growth Factor β Signaling

Jun Wei, Archit K. Ghosh, Haiyan Chu, +5

Arthritis & Rheumatology