Concepedia

NELF complex fosters BRCA1 and RAD51 recruitment to DNA damage sites and modulates sensitivity to PARP inhibition

Laila A. Bishara, Feras E. Machour, Samah W. Awwad, Nabieh Ayoub

DNA repair · 2020 · 18 citations · 17 references

DOI

Concepts

References

17

Targeting the DNA repair defect in BRCA mutant cells as a therapeutic strategy

Hannah Farmer, Nuala McCabe, Christopher J. Lord et al. · Nature · 2005 · 6.7K citations

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Specific killing of BRCA2-deficient tumours with inhibitors of poly(ADP-ribose) polymerase

Helen E. Bryant, Niklas Schultz, Huw D. Thomas et al. · Nature · 2005 · 5.2K citations

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NELF, a Multisubunit Complex Containing RD, Cooperates with DSIF to Repress RNA Polymerase II Elongation

Yuki Yamaguchi, Toshiyuki Takagi, Tadashi Wada et al. · Cell · 1999 · 832 citations · Full text

, , +12

Transcriptionally active chromatin recruits homologous recombination at DNA double-strand breaks

François Aymard, Béatrix Bugler, Christine K. Schmidt et al. · Nature Structural & Molecular Biology · 2014 · 671 citations · Full text

, , +16

A Genetic Map of the Response to DNA Damage in Human Cells

Michele Olivieri, Tiffany Cho, Alejandro Álvarez-Quilón et al. · Cell · 2020 · 567 citations · Full text

, , +16