Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells under high glucose

Chemistry and biology of reactive oxygen species in signaling or stress responses

Bryan C. Dickinson, Christopher J. Chang · Nature Chemical Biology · 2011 · 1.8K citations

Life Sciences, Biochemistry, Molecular Biology +14

Keap1 Recruits Neh2 through Binding to ETGE and DLG Motifs: Characterization of the Two-Site Molecular Recognition Model

Kit I. Tong, Yasutake Katoh, Hideki Kusunoki et al. · Molecular and Cellular Biology · 2006 · 738 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer

Balasundaram Padmanabhan, Kit I. Tong, Tsutomu Ohta et al. · Molecular Cell · 2006 · 731 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Physiological Significance of Reactive Cysteine Residues of Keap1 in Determining Nrf2 Activity

Takafumi Suzuki, Akira Kobayashi, Junko Wakabayashi et al. · Molecular and Cellular Biology · 2008 · 501 citations

Life Sciences, Biochemistry, Molecular Biology +14

The Protective Role of Nrf2 in Streptozotocin-Induced Diabetic Nephropathy

Tao Jiang, Zheping Huang, Yifeng Lin et al. · Diabetes · 2010 · 434 citations · Full text

Medicine, Nephrology, Pathobiology +17