Huilian Hua

Discovery of novel and potent dual-targeting AXL/HDAC2 inhibitors for colorectal cancer treatment via structure-based pharmacophore modelling, virtual screening, and molecular docking, molecular dynamics simulation studies, and biological evaluation

Xiangyu Wu, Shutong Chen, Miaomiao Niu et al. · Journal of Enzyme Inhibition and Medicinal Chemistry · 2023 · 33 citations · Full text

Medicine, Medicinal Chemistry, Oncology +17

Discovery of a coumarin derivative as Nrf2 activator mitigating oxidative stress and fibrosis in mesangial cells under high glucose

Huankai Yao, Nan Zhang, Wenting Zhang et al. · Bioorganic & Medicinal Chemistry Letters · 2020 · 14 citations

Life Sciences, Cell Biology, Pharmacology +17

Investigating the medicinal potential, material basis and mechanism of Polygoni Orientalis Fructus based on multi-technology integrated network pharmacology

Kai Chen, Jianjiang Qu, Hongwei Chen et al. · Phytomedicine · 2021 · 12 citations

Life Sciences, Medicinal Chemistry, Pharmacology +17

Discovery of polypodiside as a Keap1-dependent Nrf2 activator attenuating oxidative stress and accumulation of extracellular matrix in glomerular mesangial cells under high glucose

Huankai Yao, Nan Zhang, Wenting Zhang et al. · Bioorganic & Medicinal Chemistry · 2020 · 10 citations

Life Sciences, Biochemistry, Cell Biology +14