Tsutomu Ohta

G9a histone methyltransferase plays a dominant role in euchromatic histone H3 lysine 9 methylation and is essential for early embryogenesis

Makoto Tachibana, Kenji Sugimoto, Masami Nozaki et al. · Genes & Development · 2002 · 1.2K citations · Full text

Life Sciences, Genetics, Molecular Biology +16

Histone methyltransferases G9a and GLP form heteromeric complexes and are both crucial for methylation of euchromatin at H3-K9

Makoto Tachibana, Jun Ueda, Mikiko Fukuda et al. · Genes & Development · 2005 · 830 citations · Full text

Life Sciences, Genetics, Molecular Biology +17

Structural Basis for Defects of Keap1 Activity Provoked by Its Point Mutations in Lung Cancer

Balasundaram Padmanabhan, Kit I. Tong, Tsutomu Ohta et al. · Molecular Cell · 2006 · 731 citations · Full text

Life Sciences, Genetics, Molecular Biology +13

Cancer related mutations in <i>NRF2</i> impair its recognition by Keap1-Cul3 E3 ligase and promote malignancy

Tatsuhiro Shibata, Tsutomu Ohta, Kit I. Tong et al. · Proceedings of the National Academy of Sciences · 2008 · 721 citations · Full text

Medicine, Cancer Biology, Molecular Biology +14

Loss of Keap1 Function Activates Nrf2 and Provides Advantages for Lung Cancer Cell Growth

Tsutomu Ohta, Kumiko Iijima, Mamiko Miyamoto et al. · Cancer Research · 2008 · 628 citations

Medicine, Genetics, Oncology +15