The covalent NLRP3-inflammasome inhibitor Oridonin relieves myocardial infarction induced myocardial fibrosis and cardiac remodeling in mice

A small-molecule inhibitor of the NLRP3 inflammasome for the treatment of inflammatory diseases

Rebecca C. Coll, Avril A. B. Robertson, Jae Jin Chae et al. · Nature Medicine · 2015 · 2.8K citations · Full text

Life Sciences, Immunology, Medicinal Chemistry +15

Identification of Splenic Reservoir Monocytes and Their Deployment to Inflammatory Sites

Filip K. Świrski, Matthias Nahrendorf, Martin Etzrodt et al. · Science · 2009 · 2.2K citations · Full text

Life Sciences, Cell Biology, Immunology +17

Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

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Life Sciences, Immunology, Medicinal Chemistry +17

Identification of a selective and direct NLRP3 inhibitor to treat inflammatory disorders

Hua Jiang, Hongbin He, Yun Chen et al. · The Journal of Experimental Medicine · 2017 · 729 citations · Full text

Life Sciences, Medicinal Chemistry, Molecular Biology +15

Neutrophils orchestrate post-myocardial infarction healing by polarizing macrophages towards a reparative phenotype

Michael Horckmans, Larisa Ring, Johan Duchêne et al. · European Heart Journal · 2016 · 720 citations · Full text

Life Sciences, Immunology, Pathology +17