Oridonin is a covalent NLRP3 inhibitor with strong anti-inflammasome activity

Hongbin He, Hua Jiang, Yun Chen, +8

Nature Communications

InflammationCovalent Nlrp3 InhibitorNlrp3 Inflammasome AssemblyAnti-inflammatoryAutoimmune Disease +12

Tranilast directly targets <scp>NLRP</scp> 3 to treat inflammasome‐driven diseases

Yi Huang, Hua Jiang, Yun Chen, +8

EMBO Molecular Medicine

Profiling circRNA and miRNA of radiation-induced esophageal injury in a rat model

Judong Luo, Changsong Zhang, Qiang Zhan, +4

Scientific Reports

Radiation-induced Esophageal InjuryRadiation MedicineSystems BiologyRadiation BiologyMicro Ribonucleic Acid +13

miR-30e-5p Alleviates Inflammation and Cardiac Dysfunction After Myocardial Infarction Through Targeting PTEN

Yongli Chen, Yan Yin, Hua Jiang

Inflammation

InflammationHeart FailureCardiac ReprogrammingCardiovascular DiseaseAtherosclerosis +10

Serum MicroRNAs as Diagnostic Biomarkers for Macrosomia

Hua Jiang, Yang Wen, Lingmin Hu, +3

Reproductive Sciences

EngineeringDiagnostic BiomarkersGeneticsMedicinePathology +8

Single-cell RNA sequencing reveals immune microenvironment niche transitions during the invasive and metastatic processes of ground-glass nodules and part-solid nodules in lung adenocarcinoma

Yifeng Ren, Qiong Ma, Xiao Zeng, +17

Molecular Cancer

Expression of Gli1 and Wnt2B correlates with progression and clinical outcome of pancreatic cancer.

Hua Jiang, Fengru Li, Chengzhi He, +3

PubMed

Discovery and optimization of 4-oxo-2-thioxo-thiazolidinones as NOD-like receptor (NLR) family, pyrin domain-containing protein 3 (NLRP3) inhibitors

Yun Chen, Hongbin He, Hua Jiang, +6

Bioorganic & Medicinal Chemistry Letters

Medicinal ChemistryDrug TargetBioorganic ChemistryBiochemistryNatural Sciences +10

Up-regulation of miR-498 inhibits cell proliferation, invasion and migration of hepatocellular carcinoma by targeting FOXO3

Wenqin Li, Hua Jiang

Clinics and Research in Hepatology and Gastroenterology

Hepatocellular CarcinomaMedicineLiver PhysiologyMicrorna DetectionCell Biology +8

Preventive Effect of Gonggan (Citrus Reticulata Blanco Var. Gonggan) Peel Extract on Ethanol/HCl-Induced Gastric Injury in Mice via an Anti-oxidative Mechanism

Ya Wu, Hua Jiang, Guangfang Chen, +5

Frontiers in Pharmacology