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Indole microbial intestinal metabolites expand the repertoire of ligands and agonists of the human pregnane X receptor

Peter Illéš, Kristýna Krasulová, Barbora Vyhlídalová, Karolína Poulíková, Adéla Marcalíková, Petra Pečinková, Natália Sirotová, Radim Vrzal, Sridhar Mani, Zdeněk Dvořák

Toxicology Letters · 2020 · 64 citations · 31 references

DOI

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References

31

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

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An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

, , +16

Type I interferons and microbial metabolites of tryptophan modulate astrocyte activity and central nervous system inflammation via the aryl hydrocarbon receptor

Veit Rothhammer, Iván Mascanfroni, Lukas Bunse et al. · Nature Medicine · 2016 · 1.5K citations · Full text

, , +17

CARD9 impacts colitis by altering gut microbiota metabolism of tryptophan into aryl hydrocarbon receptor ligands

Bruno Lamas, Mathias L. Richard, Valentin Leducq et al. · Nature Medicine · 2016 · 1.4K citations · Full text

, , +16

The nuclear receptor PXR is a lithocholic acid sensor that protects against liver toxicity

Jeff L. Staudinger, Bryan Goodwin, Stacey A. Jones et al. · Proceedings of the National Academy of Sciences · 2001 · 1.4K citations · Full text

, , +13