John T. Moore

The human orphan nuclear receptor PXR is activated by compounds that regulate CYP3A4 gene expression and cause drug interactions.

J�rgen Lehmann, David D. McKee, M. A. Watson et al. · Journal of Clinical Investigation · 1998 · 1.6K citations · Full text

Medicine, Molecular Biology, Pharmacology +14

An Orphan Nuclear Receptor Activated by Pregnanes Defines a Novel Steroid Signaling Pathway

Steven A. Kliewer, John T. Moore, Laura Wade et al. · Cell · 1998 · 1.5K citations · Full text

Life Sciences, Biochemistry, Endocrinology +16

Crystal Structure of the Glucocorticoid Receptor Ligand Binding Domain Reveals a Novel Mode of Receptor Dimerization and Coactivator Recognition

Randy K. Bledsoe, Valerie G. Montana, Thomas B. Stanley et al. · Cell · 2002 · 815 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +17

Nuclear Pregnane X Receptor and Constitutive Androstane Receptor Regulate Overlapping but Distinct Sets of Genes Involved in Xenobiotic Detoxification

Jodi M. Maglich, Catherine M. Stoltz, Bryan Goodwin et al. · Molecular Pharmacology · 2002 · 652 citations

Medicine, Pharmacology, Toxicology +16

Structural basis for antagonist-mediated recruitment of nuclear co-repressors by PPARα

H. Eric Xu, Thomas B. Stanley, Valerie G. Montana et al. · Nature · 2002 · 611 citations

Life Sciences, Biochemistry, Molecular Biology +16