Concepedia

Targeting dual tolerant regions of binding pocket: Discovery of novel morpholine-substituted diarylpyrimidines as potent HIV-1 NNRTIs with significantly improved water solubility

Zhao Wang, Dongwei Kang, Da Feng, Srinivasulu Cherukupalli, Xiangyi Jiang, Zhipeng Fu, Erik De Clercq, Christophe Pannecouque, Xinyong Liu, Peng Zhan

European Journal of Medicinal Chemistry · 2020 · 14 citations · 31 references

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References

31

Rapid and automated tetrazolium-based colorimetric assay for the detection of anti-HIV compounds

Rudi Pauwels, Jan Balzarini, Masanori Baba et al. · Journal of Virological Methods · 1988 · 1.6K citations

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ADMETlab: a platform for systematic ADMET evaluation based on a comprehensively collected ADMET database

Jie Dong, Ningning Wang, Zhi‐Jiang Yao et al. · Journal of Cheminformatics · 2018 · 857 citations · Full text

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Polar Molecular Surface Properties Predict the Intestinal Absorption of Drugs in Humans

Katrin Palm, Patric Stenberg, Kristina Luthman et al. · Pharmaceutical Research · 1997 · 751 citations

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Computational methods for the prediction of ‘drug-likeness’

David E. Clark, Stephen D. Pickett · Drug Discovery Today · 2000 · 573 citations

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Tetrazolium-based colorimetric assay for the detection of HIV replication inhibitors: revisited 20 years later

Christophe Pannecouque, Dirk Daelemans, Erik De Clercq · Nature Protocols · 2008 · 349 citations

, , +14