Concepedia

Selective Delivery of Dicarboxylates to Mitochondria by Conjugation to a Lipophilic Cation via a Cleavable Linker

Hiran A. Prag, Duvaraka Kula‐Alwar, Laura Pala, Stuart T. Caldwell, Timothy E. Beach, Andrew M. James, Kourosh Saeb‐Parsy, Thomas Krieg, Richard C. Hartley, Michael P. Murphy

Molecular Pharmaceutics · 2020 · 30 citations · 42 references

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Concepts

Abstract

. Therefore, we have developed a TPP-monoester platform that enables the selective release of bioactive dicarboxylates within mitochondria.

References

42

Ischaemic accumulation of succinate controls reperfusion injury through mitochondrial ROS

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Itaconate is an anti-inflammatory metabolite that activates Nrf2 via alkylation of KEAP1

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Delivery of bioactive molecules to mitochondria <i>in</i> <i>vivo</i>

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Edward T. Chouchani, Carmen Methner, Sergiy M. Nadtochiy et al. · Nature Medicine · 2013 · 614 citations · Full text

, , +14