Concepedia

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Julia M. D. Grandjean, Aparajita Madhavan, Lauren Čech, Bryan O. Seguinot, Ryan J Paxman, Emery Smith, Louis Scampavia, Evan T. Powers, Christina B. Cooley, Lars Plate,

Nature Chemical Biology · 2020 · 184 citations · 41 references

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41

Mutation of the mouse klotho gene leads to a syndrome resembling ageing.

PubMed · 1997 · 66.6K citations

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XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Hiderou Yoshida, Toshie Matsui, Akira Yamamoto et al. · Cell · 2001 · 4.1K citations · Full text

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Endoplasmic Reticulum Stress Links Obesity, Insulin Action, and Type 2 Diabetes

Umut Özcan, Qiong Cao, Erkan Yılmaz et al. · Science · 2004 · 3.8K citations

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Coupling of Stress in the ER to Activation of JNK Protein Kinases by Transmembrane Protein Kinase IRE1

Fumihiko Urano, Xiao-Zhong Wang, Anne Bertolotti et al. · Science · 2000 · 3K citations

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XBP-1 Regulates a Subset of Endoplasmic Reticulum Resident Chaperone Genes in the Unfolded Protein Response

Ann–Hwee Lee, Neal N. Iwakoshi, Laurie H. Glimcher · Molecular and Cellular Biology · 2003 · 2.1K citations · Full text

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