XBP1 mRNA Is Induced by ATF6 and Spliced by IRE1 in Response to ER Stress to Produce a Highly Active Transcription Factor

Hiderou Yoshida, Toshie Matsui, Akira Yamamoto, +2

Cell

Transcriptional RegulationSignal TransductionMolecular RegulationGeneticsGene Expression +7

Mammalian Transcription Factor ATF6 Is Synthesized as a Transmembrane Protein and Activated by Proteolysis in Response to Endoplasmic Reticulum Stress

Kyosuke Haze, Hiderou Yoshida, Hideki Yanagi, +2

Molecular Biology of the Cell

Protein FunctionSignal TransductionProtein ExpressionYeast UprProtein Folding +13

Identification of the cis-Acting Endoplasmic Reticulum Stress Response Element Responsible for Transcriptional Induction of Mammalian Glucose-regulated Proteins

Hiderou Yoshida, Kyosuke Haze, Hideki Yanagi, +2

Journal of Biological Chemistry

IRE1-mediated unconventional mRNA splicing and S2P-mediated ATF6 cleavage merge to regulate XBP1 in signaling the unfolded protein response

Kyung‐Ho Lee, Witoon Tirasophon, Xiaohua Shen, +6

Genes & Development

Transcriptional Induction of Mammalian ER Quality Control Proteins Is Mediated by Single or Combined Action of ATF6α and XBP1

Keisuke Yamamoto, Takashi Sato, Toshie Matsui, +5

Developmental Cell

Transcriptional RegulationProtein Quality ControlSignal TransductionSignaling PathwayCell Regulation +10

ATF6 Activated by Proteolysis Binds in the Presence of NF-Y (CBF) Directly to the<i>cis</i>-Acting Element Responsible for the Mammalian Unfolded Protein Response

Hiderou Yoshida, Tetsuya Okada, Kyosuke Haze, +3

Molecular and Cellular Biology

Complementary Signaling Pathways Regulate the Unfolded Protein Response and Are Required for C. elegans Development

Xiaohua Shen, Ronald Ellis, Kyung‐Ho Lee, +8

Cell

Signal TransductionDevelopmental BiologyC. Elegans DevelopmentSignaling PathwayMolecular Pathway +7

A Time-Dependent Phase Shift in the Mammalian Unfolded Protein Response

Hiderou Yoshida, Toshie Matsui, Nobuko Hosokawa, +3

Developmental Cell

Protein FunctionSignal TransductionProtein FoldingUnfolded Protein ResponseMolecular Biology +6

XBP1 Is Essential for Survival under Hypoxic Conditions and Is Required for Tumor Growth

Lorenzo Romero‐Ramírez, Hongbin Cao, Daniel W. Nelson, +9

Cancer Research

Distinct roles of activating transcription factor 6 (ATF6) and double-stranded RNA-activated protein kinase-like endoplasmic reticulum kinase (PERK) in transcription during the mammalian unfolded protein response

Tetsuya Okada, Hiderou Yoshida, Rieko Akazawa, +1

Biochemical Journal