Lars Plate

“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

D.E. Mortenson, Gabriel J. Brighty, Lars Plate et al. · Journal of the American Chemical Society · 2017 · 305 citations · Full text

Pharmacy, Biochemistry, Medicinal Chemistry +13

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

Wentao Chen, Jiajia Dong, Lars Plate et al. · Journal of the American Chemical Society · 2016 · 294 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +11

Toward ‘Omic Scale Metabolite Profiling: A Dual Separation–Mass Spectrometry Approach for Coverage of Lipid and Central Carbon Metabolism

Julijana Ivanišević, Zheng‐Jiang Zhu, Lars Plate et al. · Analytical Chemistry · 2013 · 269 citations · Full text

Life Sciences, Biochemistry, Mass Spectrometric Analysis +16

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Lars Plate, Christina B. Cooley, John J. Chen et al. · eLife · 2016 · 253 citations · Full text

Life Sciences, Biochemistry, Molecular Biology +13

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf et al. · Nature Communications · 2019 · 198 citations · Full text

Life Sciences, Cell Biology, Molecular Biology +14