Christina B. Cooley

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Lars Plate, Christina B. Cooley, John J. Chen et al. · eLife · 2016 · 248 citations · Full text

Molecular Biology, Cellular Physiology, Global Er Stress +17

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Julia M. D. Grandjean, Aparajita Madhavan, Lauren Čech et al. · Nature Chemical Biology · 2020 · 166 citations · Full text

Transcriptional Regulation, Er Proteostasis, Signal Transduction +4

Oligocarbonate Molecular Transporters: Oligomerization-Based Syntheses and Cell-Penetrating Studies

Christina B. Cooley, Brian M. Trantow, Fredrik Nederberg et al. · Journal of the American Chemical Society · 2009 · 120 citations · Full text

1,7-Side Chain Spacing, Cell-based Drug Delivery, Medicinal Chemistry +15

Designed guanidinium-rich amphipathic oligocarbonate molecular transporters complex, deliver and release siRNA in cells

Erika I. Geihe, Christina B. Cooley, Jeff Simon et al. · Proceedings of the National Academy of Sciences · 2012 · 118 citations · Full text

Medicinal Chemistry, Engineering, Biochemistry +15

Unfolded protein response activation reduces secretion and extracellular aggregation of amyloidogenic immunoglobulin light chain

Christina B. Cooley, Lisa M. Ryno, Lars Plate et al. · Proceedings of the National Academy of Sciences · 2014 · 92 citations · Full text

Protein Secretion, Molecular Biology, Neurochemical Biomarkers +27