Gabriel J. Brighty

“Inverse Drug Discovery” Strategy To Identify Proteins That Are Targeted by Latent Electrophiles As Exemplified by Aryl Fluorosulfates

D.E. Mortenson, Gabriel J. Brighty, Lars Plate et al. · Journal of the American Chemical Society · 2017 · 299 citations · Full text

Arylfluorosulfates Inactivate Intracellular Lipid Binding Protein(s) through Chemoselective SuFEx Reaction with a Binding Site Tyr Residue

Wentao Chen, Jiajia Dong, Lars Plate et al. · Journal of the American Chemical Society · 2016 · 288 citations · Full text

Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery

Gabriel J. Brighty, Rachel C. Botham, Suhua Li et al. · Nature Chemistry · 2020 · 140 citations · Full text

Medicinal Chemistry, Antimicrobial Drug Discovery, Medicine +12

Predictive model of response to tafamidis in hereditary ATTR polyneuropathy

Cecília Monteiro, Jaleh S. Mesgazardeh, João Anselmo et al. · JCI Insight · 2019 · 82 citations · Full text

Divergent Modulation of Src-Family Kinase Regulatory Interactions with ATP-Competitive Inhibitors

Stephen E. Leonard, Ames C. Register, Ratika Krishnamurty et al. · ACS Chemical Biology · 2014 · 27 citations · Full text

Molecular Regulation, Molecular Biology, Analytical Ultracentrifugation +19