Rachel C. Botham

Using sulfuramidimidoyl fluorides that undergo sulfur(vi) fluoride exchange for inverse drug discovery

Gabriel J. Brighty, Rachel C. Botham, Suhua Li et al. · Nature Chemistry · 2020 · 140 citations · Full text

Medicinal Chemistry, Antimicrobial Drug Discovery, Medicine +12

A Small Molecule that Induces Intrinsic Pathway Apoptosis with Unparalleled Speed

Rahul Palchaudhuri, Michael J. Lambrecht, Rachel C. Botham et al. · Cell Reports · 2015 · 104 citations · Full text

Synergistic and targeted therapy with a procaspase-3 activator and temozolomide extends survival in glioma rodent models and is feasible for the treatment of canine malignant glioma patients

Avadhut D. Joshi, Rachel C. Botham, Lisa J. Schlein et al. · Oncotarget · 2017 · 46 citations · Full text

Preparation of the caspase-3/7 substrate Ac-DEVD-pNA by solution-phase peptide synthesis

Quinn P. Peterson, David R. Goode, Diana C. West et al. · Nature Protocols · 2010 · 45 citations · Full text

Bioorganic Chemistry, Biochemistry, Natural Sciences +7

Parallel Synthesis and Biological Evaluation of 837 Analogues of Procaspase-Activating Compound 1 (PAC-1)

Danny Hsu, Howard S. Roth, Diana C. West et al. · ACS Combinatorial Science · 2011 · 41 citations

Medicinal Chemistry, Biochemistry, Medicine +15