Ryan J Paxman

Small molecule proteostasis regulators that reprogram the ER to reduce extracellular protein aggregation

Lars Plate, Christina B. Cooley, John J. Chen et al. · eLife · 2016 · 248 citations · Full text

Molecular Biology, Cellular Physiology, Global Er Stress +17

Pharmacologic ATF6 activation confers global protection in widespread disease models by reprograming cellular proteostasis

Erik A. Blackwood, Khalid Azizi, Donna J. Thuerauf et al. · Nature Communications · 2019 · 193 citations · Full text

Pharmacologic IRE1/XBP1s activation confers targeted ER proteostasis reprogramming

Julia M. D. Grandjean, Aparajita Madhavan, Lauren Čech et al. · Nature Chemical Biology · 2020 · 166 citations · Full text

Transcriptional Regulation, Er Proteostasis, Signal Transduction +4

Pharmacologic ATF6 activating compounds are metabolically activated to selectively modify endoplasmic reticulum proteins

Ryan J Paxman, Lars Plate, Erik A. Blackwood et al. · eLife · 2018 · 116 citations · Full text

The unfolded protein response regulator ATF6 promotes mesodermal differentiation

Heike Kroeger, Neil Grimsey, Ryan J Paxman et al. · Science Signaling · 2018 · 79 citations · Full text