Effects of Probiotic Supplementation on Short Chain Fatty Acids in the <i>App</i>^{<i>NL</i>-<i>G</i>-<i>F</i>} Mouse Model of Alzheimer’s Disease

Abstract

These data demonstrate intestinal dysbiosis in the AppNL-G-Fmouse model of AD. Probiotic VSL#3 feeding altered both serum and brain levels of lactate and acetate in AppNL-G-Fmice correlating with increased expression of the neuronal activity marker, c-Fos.