Journal of Agricultural and Food Chemistry · 2020 · 49 citations · 32 references
PharmacyBiochemistryMolecular PharmaceuticsBiomaterialsDrug DeliveryNanoparticle Drug DeliveryCell-nanoparticle InteractionsGlycan StructureNanoparticle CharacterizationNanoparticle DesignNanoparticle-based BioavailabilitySolubility OptimizationAmorphous State CharacterizationAntioxidant BioavailabilityCaco-2 Cell AssayCellular Uptake ModulationDelivery To CarrierHydrogen Bonds In CarbohydratesNanoparticle Cellular UptakeOxidative Stress Injury
In this study, sugary maize dendrimer-like glucan (SMDG) was used as a delivery carrier for improving the bioavailability of resveratrol (RES). After optimization, the solubility of RES in RES-SMDG markedly increased to approximately 9.1 times that of the raw RES solution. The structural characterizations of the RES-SMDG formulation showed crystal RES was entrapped in the SMDG matrix for the amorphous state due to the strong intermolecular hydrogen bonds between the −OH of RES and glucan chains. In this case, antioxidant activity of RES-SMDG was markedly higher than that of the raw RES solution. In the Caco-2 cell model, the Papp value of RES in the RES-SMDG group was slightly higher than those of common permeable compounds, while the cellular uptake was significantly improved. RES-SMDG also exhibited protective effects against cellular damage under oxidative stress. The results indicated that SMDG is an attractive carrier to encapsulate and protect hydrophilic bioactive ingredients.
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Dendrimer as nanocarrier for drug delivery
Prashant Kesharwani, Keerti Jain · Progress in Polymer Science · 2013 · 1.1K citations