Klotho rewires cellular metabolism of breast cancer cells through alteration of calcium shuttling and mitochondrial activity

Mutation of the mouse klotho gene leads to a syndrome resembling ageing

Makoto Kuro‐o, Yutaka Matsumura, Hiroki Aizawa et al. · Nature · 1997 · 3.8K citations

Life Sciences, Genetics, Molecular Genetics +12

The AMPK signalling pathway coordinates cell growth, autophagy and metabolism

Maria M. Mihaylova, Reuben J. Shaw · Nature Cell Biology · 2011 · 2.9K citations · Full text

Life Sciences, Cell Biology, Molecular Biology +10

Suppression of Aging in Mice by the Hormone Klotho

Hiroshi Kurosu, Masaya Yamamoto, Jeremy D. Clark et al. · Science · 2005 · 1.9K citations · Full text

Education, Endocrinology, Genetics +17

Klotho converts canonical FGF receptor into a specific receptor for FGF23

Itaru Urakawa, Yuji Yamazaki, Takashi Shimada et al. · Nature · 2006 · 1.8K citations

Life Sciences, Genetics, Molecular Biology +10

Calmodulin-dependent protein kinase kinase-β is an alternative upstream kinase for AMP-activated protein kinase

Simon A. Hawley, David Pan, Kirsty J. Mustard et al. · Cell Metabolism · 2005 · 1.6K citations · Full text

Life Sciences, Biochemistry, Molecular Biology +7