Cytotoxic triterpenoid glycosides from leaves of <i>Cyclocarya paliurus</i>

Abstract

Three previously undescribed dammarane triterpenoid glycosides (<b>1-3</b>) along with five known analogues (<b>4-8</b>) were isolated from the leaves of <i>Cyclocarya paliurus</i>. Their structures and configurations were determined on the basis of comprehensive spectroscopic analyses, chemical hydrolysis and DFT GIAO ¹³C NMR calculation. All the isolates were evaluated cytotoxic activities against seven human cancer cell lines (MCF-7, PC-3, Du145, NCI-H1975, PC-9, SKVO3 and HepG2). Moreover, compound <b>4</b> showed a wide spectrum of cytotoxicity against human cancer cells with IC₅₀ values ranging from 11.31 to 29.51 µM.