Targeting DUSP7 signaling alleviates hepatic steatosis, inflammation and oxidative stress in high fat diet (HFD)-fed mice via suppression of TAK1

Local and systemic insulin resistance resulting from hepatic activation of IKK-β and NF-κB

Dongsheng Cai, Minsheng Yuan, Daniel Frantz et al. · Nature Medicine · 2005 · 2.2K citations · Full text

Inflammation, Metabolic Syndrome, Insulin Resistance +15

TAK1 is a ubiquitin-dependent kinase of MKK and IKK

Chen Wang, Li Deng, Mei Hong et al. · Nature · 2001 · 2.1K citations

Signal Transduction, Signaling Pathway, Cell Regulation +6

Reactive oxygen species act through p38 MAPK to limit the lifespan of hematopoietic stem cells

Keisuke Ito, Atsushi Hirao, Fumio Arai et al. · Nature Medicine · 2006 · 1.3K citations

Reactive Oxygen Species, Medicine, Stem Cell Mobilization +13

TM6SF2 rs58542926 influences hepatic fibrosis progression in patients with non-alcoholic fatty liver disease

Yang‐Lin Liu, Helen L. Reeves, Alastair D. Burt et al. · Nature Communications · 2014 · 601 citations · Full text

Heritability of Hepatic Fibrosis and Steatosis Based on a Prospective Twin Study

Rohit Loomba, Nicholas J. Schork, Chi‐Hua Chen et al. · Gastroenterology · 2015 · 374 citations · Full text

Prospective Twin Study, Fibrosis, Hepatology +11