Science Translational Medicine · 2020 · 178 citations · 45 references
Life SciencesBiomedical EngineeringImmunologyImmunoregulationInflammationInnate ImmunityCytokine BiologyForeign Body ResponseHelper T Cell SubsetsImplant MaterialsImplantation ImmunologyT Cell BiologyBiomedical ImplantsFibrotic ChangeFibrous EncapsulationInterleukin-17 ResponsesMurine ModelsStromal TissueT Helper 17 ImmunityTh17 Responses
17 immune response and the senescence response to implanted synthetic materials introduces new targets for therapeutic intervention in the foreign body response.
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Mutation of the mouse klotho gene leads to a syndrome resembling ageing.
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Senolytics improve physical function and increase lifespan in old age
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Clearance of senescent cells by ABT263 rejuvenates aged hematopoietic stem cells in mice
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Cellular senescence mediates fibrotic pulmonary disease
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