Molecular Cell · 2020 · 212 citations · 27 references
Life SciencesGeneticsMolecular BiologyGenomicsCrispr-cas SystemsGenomic ProfilingVariant AnalysisVariant CallingVariant DetectionVariant InterpretationCas9 Off-target ActivityCrispr-cas9 Allele DiscriminationCrispr-cas9 ValidationParallel Profiling
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Genome engineering using the CRISPR-Cas9 system
F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.7K citations · Full text
Genome-Scale CRISPR-Cas9 Knockout Screening in Human Cells
Ophir Shalem, Neville E. Sanjana, Ella Hartenian et al. · Science · 2013 · 5.5K citations · Full text
Search-and-replace genome editing without double-strand breaks or donor DNA
Andrew V. Anzalone, Peyton B. Randolph, Jessie R. Davis et al. · Nature · 2019 · 4.7K citations · Full text
High-fidelity CRISPR–Cas9 nucleases with no detectable genome-wide off-target effects
Benjamin P. Kleinstiver, Vikram Pattanayak, Michelle S. Prew et al. · Nature · 2016 · 2.7K citations · Full text
Rationally engineered Cas9 nucleases with improved specificity
Ian M. Slaymaker, Linyi Gao, Bernd Zetsche et al. · Science · 2015 · 2.5K citations