Fabrication and characterization of PLGA nanoparticles encapsulating large CRISPR–Cas9 plasmid

Genome engineering using the CRISPR-Cas9 system

F. Ann Ran, Patrick D. Hsu, Jason Wright et al. · Nature Protocols · 2013 · 11.4K citations · Full text

Engineering, Genome Surgery, Genetics +7

Defective LPS Signaling in C3H/HeJ and C57BL/10ScCr Mice: Mutations in <i>Tlr4</i> Gene

Alexander Poltorak, Xiaolong He, Irina Smirnova et al. · Science · 1998 · 7.5K citations

A Single Administration of CRISPR/Cas9 Lipid Nanoparticles Achieves Robust and Persistent In Vivo Genome Editing

Jonathan D. Finn, Amy Smith, Mihir Patel et al. · Cell Reports · 2018 · 801 citations · Full text

CRISPR-mediated direct mutation of cancer genes in the mouse liver

Wen Xue, Sidi Chen, Hao Yin et al. · Nature · 2014 · 780 citations · Full text

Nanoparticle delivery of Cas9 ribonucleoprotein and donor DNA in vivo induces homology-directed DNA repair

Kunwoo Lee, Michael J. Conboy, Hyo Min Park et al. · Nature Biomedical Engineering · 2017 · 726 citations · Full text

Dna Nanotechnology, In Vivo Gene Therapy, Nanoparticle Delivery +7