Concepedia

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Christian Bogner, Justin Kale, Justin Pogmore, Xiaoke Chi, Aisha Shamas‐Din, Cécile Fradin, Brian Leber, David W. Andrews

Molecular Cell · 2020 · 41 citations · 27 references

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27

ABT-199, a potent and selective BCL-2 inhibitor, achieves antitumor activity while sparing platelets

Andrew J. Souers, Joel D. Leverson, Erwin R. Boghaert et al. · Nature Medicine · 2013 · 3K citations

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Distinct BH3 domains either sensitize or activate mitochondrial apoptosis, serving as prototype cancer therapeutics

Anthony Letai, Michael C. Bassik, Loren D. Walensky et al. · Cancer Cell · 2002 · 1.6K citations · Full text

, , +16

BID: a novel BH3 domain-only death agonist.

Kai Wang, Xiaoming Yin, Debra T. Chao et al. · Genes & Development · 1996 · 962 citations · Full text

, , +16

Fluorescence cross-correlation spectroscopy in living cells

Kirsten Bacia, Sally A. Kim, Petra Schwille · Nature Methods · 2006 · 633 citations

, , +14

Bcl-xL Retrotranslocates Bax from the Mitochondria into the Cytosol

Frank Edlich, Soojay Banerjee, Motoshi Suzuki et al. · Cell · 2011 · 617 citations · Full text

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