Justin Kale

<scp>BH</scp> 3‐in‐groove dimerization initiates and helix 9 dimerization expands Bax pore assembly in membranes

Zhi Zhang, Sabareesh Subramaniam, Justin Kale et al. · The EMBO Journal · 2015 · 92 citations · Full text

Membrane Structure, Proteinlipid Interaction, Membrane Formation +7

Phosphorylation switches Bax from promoting to inhibiting apoptosis thereby increasing drug resistance

Justin Kale, Özgür Kütük, Glauber C. Brito et al. · EMBO Reports · 2018 · 90 citations · Full text

Bcl-xL acts as an inhibitor of IP3R channels, thereby antagonizing Ca2+-driven apoptosis

Nicolas Rosa, Hristina Ivanova, Larry E. Wagner et al. · Cell Death and Differentiation · 2021 · 79 citations · Full text

After Embedding in Membranes Antiapoptotic Bcl-XL Protein Binds Both Bcl-2 Homology Region 3 and Helix 1 of Proapoptotic Bax Protein to Inhibit Apoptotic Mitochondrial Permeabilization

Jingzhen Ding, Blaine H. M. Mooers, Zhi Zhang et al. · Journal of Biological Chemistry · 2014 · 76 citations · Full text

Proapoptotic Bax Protein, Mitochondrial Function, Biochemistry +9

Allosteric Regulation of BH3 Proteins in Bcl-xL Complexes Enables Switch-like Activation of Bax

Christian Bogner, Justin Kale, Justin Pogmore et al. · Molecular Cell · 2020 · 40 citations · Full text

Molecular Physiology, Signal Transduction, Allosteric Regulation +8