Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

Targeting focal adhesion kinase renders pancreatic cancers responsive to checkpoint immunotherapy

Hong Jiang, Samarth Hegde, Brett L. Knolhoff et al. · Nature Medicine · 2016 · 1K citations · Full text

Medicine, Cancer Biology, Oncology +10

Nuclear FAK Controls Chemokine Transcription, Tregs, and Evasion of Anti-tumor Immunity

Alan Serrels, Tom Lund, Bryan Serrels et al. · Cell · 2015 · 417 citations · Full text

Medicine, Immunology, Oncology +17

Tumor-initiating stem cells of squamous cell carcinomas and their control by TGF-β and integrin/focal adhesion kinase (FAK) signaling

Markus Schöber, Elaine Fuchs · Proceedings of the National Academy of Sciences · 2011 · 260 citations · Full text

Medicine, Cell Biology, Oncology +17

Inhibition of Focal Adhesion Kinase by PF-562,271 Inhibits the Growth and Metastasis of Pancreatic Cancer Concomitant with Altering the Tumor Microenvironment

Jayme B. Stokes, Sara J. Adair, Jill K. Slack‐Davis et al. · Molecular Cancer Therapeutics · 2011 · 240 citations · Full text

Medicine, Cancer Biology, Oncology +17

Overexpression of focal adhesion kinase, a protein tyrosine kinase, in ovarian carcinoma

Patricia L. Judson, Xiaping He, William G. Cance et al. · Cancer · 1999 · 183 citations

Medicine, Oncology, Pathology +16