MIR21 Drives Resistance to Heat Shock Protein 90 Inhibition in Cholangiocarcinoma

Andrea Lampis, Pietro Carotenuto, Georgios Vlachogiannis, +31

Gastroenterology

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

Ruifeng Wang, Sijia Yu, Xiangxin Zhao, +6

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryPotent Fak InhibitorsMedicine +9

Elevated systemic immune inflammation level increases the risk of total and cause-specific mortality among patients with chronic kidney disease: a large multi-center longitudinal study

Wenguang Lai, Yun Xie, Xiaoli Zhao, +9

Inflammation Research

InflammationGlomerulonephritisRenal DiseaseCause-specific MortalityMedicine +9

Comprehensive profiling of Lingzhihuang capsule by liquid chromatography coupled with mass spectrometry-based molecular networking and target prediction

Mengliang Huang, Sijia Yu, Qing Shao, +5

Acupuncture and Herbal Medicine

EngineeringMedicinal ChemistryPhytopharmacologyAnalytical ChemistryLingzhihuang Capsule +17

A CpG island methylator phenotype in acute myeloid leukemia independent of IDH mutations and associated with a favorable outcome

Andrew D. Kelly, Heike Kroeger, Jumpei Yamazaki, +16

Leukemia

Hematological MalignancyEngineeringMedicineGeneticsAcute Myeloid Leukemia +10

Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents

Ruifeng Wang, Yixuan Chen, Xiangxin Zhao, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

Silence of lncRNA MIAT-mediated inhibition of DLG3 promoter methylation suppresses breast cancer progression via the Hippo signaling pathway

Dezhi Li, Xingsheng Hu, Sijia Yu, +4

Cellular Signalling

Lncrna Miat-mediated InhibitionMedicineEpigenetic ChangeLong Non-coding RnaBreast Cancer +9

Liver RBFOX2 regulates cholesterol homeostasis via Scarb1 alternative splicing in mice

Helen A.B. Paterson, Sijia Yu, Natalia Artigas, +19

Nature Metabolism

Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrrolo[2,3-b]pyridine derivatives as potential anti-tumor agents

Ruifeng Wang, Yixuan Chen, Bowen Yang, +6

Bioorganic Chemistry

Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicinePotential Anti-tumor Agents +9

The AdcR-regulated AdcA and AdcAII contribute additively to zinc acquisition and virulence in Streptococcus suis

Chengkun Zheng, Jun Qiu, Xiaoxian Zhao, +5

Veterinary Microbiology