Design, synthesis, and structure-activity relationship studies of benzothiazole derivatives as antifungal agents

Shizhen Zhao, Liyu Zhao, Xiangqian Zhang, +6

European Journal of Medicinal Chemistry

Antifungal AgentAntifungal AgentsMedicineStructure-activity Relationship StudiesAntimicrobial Compound +5

Structure-Based Design of 6-Chloro-4-aminoquinazoline-2-carboxamide Derivatives as Potent and Selective p21-Activated Kinase 4 (PAK4) Inhibitors

Chenzhou Hao, Fan Zhao, Hongyan Song, +19

Journal of Medicinal Chemistry

Combinatorial ChemistryDrug TargetPak4 InhibitorsRemarkable Pak4 SelectivityChemical Biology +14

Discovery of biphenyl imidazole derivatives as potent antifungal agents: Design, synthesis, and structure-activity relationship studies

Dongmei Zhao, Shizhen Zhao, Liyu Zhao, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAntifungal AgentAntifungal AgentsDrug DiscoveryBiphenyl Imidazole Derivatives +7

Design, synthesis and evaluation of aromatic heterocyclic derivatives as potent antifungal agents

Shizhen Zhao, Xiangqian Zhang, Wei Peng, +7

European Journal of Medicinal Chemistry

Antifungal AgentHeterocyclicAntifungal AgentsMedicineOrganic Chemistry +5

Design, synthesis, biological evaluation and molecular docking study of novel thieno[3,2-d]pyrimidine derivatives as potent FAK inhibitors

Ruifeng Wang, Sijia Yu, Xiangxin Zhao, +6

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryPotent Fak InhibitorsMedicine +9

Discovery of indolin-2-one derivatives as potent PAK4 inhibitors: Structure-activity relationship analysis, biological evaluation and molecular docking study

Jing Guo, Mingyue Zhu, Tianxiao Wu, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryBiochemistryMedicineNatural SciencesPharmacology +8

Design, synthesis and biological evaluation of novel 7H-pyrrolo[2,3-d]pyrimidine derivatives as potential FAK inhibitors and anticancer agents

Ruifeng Wang, Yixuan Chen, Xiangxin Zhao, +7

European Journal of Medicinal Chemistry

Combinatorial ChemistryMedicinal ChemistryBiochemistryMedicineNatural Sciences +7

An orally bioavailable SARS-CoV-2 main protease inhibitor exhibits improved affinity and reduced sensitivity to mutations

Michael Westberg, Yichi Su, Xinzhi Zou, +19

Science Translational Medicine

Design, synthesis and evaluation of benzoheterocycle analogues as potent antifungal agents targeting CYP51

Shizhen Zhao, Wei Peng, Mengya Wu, +7

Bioorganic & Medicinal Chemistry

Medicinal ChemistryAntifungal AgentBiochemistryAntifungal AgentsNatural Sciences +9

Design, synthesis, biological evaluation and molecular modeling of novel 1H-pyrrolo[2,3-b]pyridine derivatives as potential anti-tumor agents

Ruifeng Wang, Yixuan Chen, Bowen Yang, +6

Bioorganic Chemistry

Combinatorial ChemistryMedicinal ChemistryNatural SciencesMedicinePotential Anti-tumor Agents +9