NEDD4 and NEDD4L regulate Wnt signalling and intestinal stem cell priming by degrading LGR5 receptor

Comprehensive molecular characterization of human colon and rectal cancer

Nature · 2012 · 8.5K citations · Full text

Medicine, Colorectal Cancer, Pathology +5

Single Lgr5 stem cells build crypt-villus structures in vitro without a mesenchymal niche

Toshiro Sato, Robert G.J. Vries, Hugo J.G. Snippert et al. · Nature · 2009 · 6.9K citations

Regenerative Medicine, Cell Lineage, Crypt-villus Structures +9

Identification of stem cells in small intestine and colon by marker gene Lgr5

Nick Barker, Johan H. van Es, Jeroen Kuipers et al. · Nature · 2007 · 5.6K citations

Cell Lineage, Cell Specialization, Marker Gene Lgr5 +10

β-catenin is a target for the ubiquitin–proteasome pathway

Hermann Aberle, Andreas Bauer, Jörg Stappert et al. · The EMBO Journal · 1997 · 2.5K citations · Full text

Protein Function, Molecular Regulation, Medicine +6

Crypt stem cells as the cells-of-origin of intestinal cancer

Nick Barker, Rachel A. Ridgway, Johan H. van Es et al. · Nature · 2008 · 2.1K citations

Medicine, Adult Stem Cell, Stem Cell Research +4