ACS Chemical Biology · 2019 · 46 citations · 44 references
Life SciencesCell BiologyMolecular BiologyCell SignalingTranscriptionTranscriptional RegulationLigand BindingRna-protein InteractionsStructural MotifsTranscription FactorsBinding Pocket DesignBinding Pocket GeometryCoactivator RecruitmentHippo SignalingRna Sequencing (Rna-seq)Transcriptional Coactivators In Signal ResponseYap And Taz SignalingYap Signaling
wound closure in a mouse wound-healing model. Although small molecules that occupy the PBP have been shown to inhibit YAP/TAZ-TEAD activity, leveraging PBP to activate TEADs is a novel approach.
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