Concepedia

Binding Pocket Geometry

Binding Pocket Geometry is the three-dimensional structural configuration of a substrate-binding site in an enzyme or receptor that determines its specificity and affinity for molecular recognition through the spatial arrangement of complementary physicochemical features.

1.1K

Publications

62.3K

Citations

5.6K

Authors

1.3K

Institutions

Publications per year

2017–2026

311

Parents

Publications

1.1K

Fpocket: An open source platform for ligand pocket detection

Vincent Le Guilloux, Peter Schmidtke, Pierre Tufféry · BMC Bioinformatics · 2009 · 1.7K citations · Full text

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Structure of the Human Dopamine D3 Receptor in Complex with a D2/D3 Selective Antagonist

Ellen Y. T. Chien, Wei Liu, Qiang Zhao et al. · Science · 2010 · 1.1K citations

, , +17

Anatomy of protein pockets and cavities: Measurement of binding site geometry and implications for ligand design

Jie Liang, Clare Woodward, Herbert Edelsbrunner · Protein Science · 1998 · 1.1K citations · Full text

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Automated docking with grid‐based energy evaluation

Elaine C. Meng, Brian K. Shoichet, Irwin D. Kuntz · Journal of Computational Chemistry · 1992 · 937 citations

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Crystal Structure Analysis of Warfarin Binding to Human Serum Albumin

I. Petitpas, Ananyo A. Bhattacharya, Sue Twine et al. · Journal of Biological Chemistry · 2001 · 820 citations · Full text

, , +17

1–5 of 1.1K

Authors

5.6K

  1. GK
    G. Klebe

    Philipps University of Marburg, Germany

    8 publications · 542 citations

    8

    h-index

  2. LS
    Lei Shi

    Cornell University, United States

    7 publications · 1.6K citations

    7

    h-index

  3. EE
    Emanuel Escher

    Université de Sherbrooke, Canada

    6 publications · 166 citations

    6

    h-index

  4. RL
    Richard Leduc

    Université de Sherbrooke, Canada

    6 publications · 166 citations

    6

    h-index

  5. GG
    Gaétan Guillemette

    Université de Sherbrooke, Canada

    6 publications · 166 citations

    6

    h-index

1–5 of 5.6K

Institutions

1.3K

  1. Centre National de la Recherche Scientifique

    Paris, France

    23 h-index

    134 publications

    9.8K citations

  2. Chinese Academy of Sciences

    Beijing, China

    19 h-index

    110 publications

    4.7K citations

  3. University of California San Diego

    San Diego, United States

    17 h-index

    69 publications

    6.2K citations

  4. Scripps Research Institute

    San Diego, United States

    17 h-index

    66 publications

    10.1K citations

  5. National Institutes of Health

    Bethesda, United States

    16 h-index

    70 publications

    4.3K citations

  6. Howard Hughes Medical Institute

    Chevy Chase, United States

    16 h-index

    35 publications

    3.7K citations

  7. Inserm

    Paris, France

    16 h-index

    77 publications

    7.9K citations

  8. University of Oxford

    Oxford, United Kingdom

    15 h-index

    65 publications

    5.1K citations

1–8 of 1.3K

Venues

  1. Journal of Biological Chemistry

    JBC · 79 publications · 5.9K citations

    42

    h-index

  2. Journal of Medicinal Chemistry

    65 publications · 4.8K citations

    36

    h-index

  3. Proceedings of the National Academy of Sciences

    PNAS · 41 publications · 4.4K citations

    35

    h-index

  4. Biochemistry

    71 publications · 3.5K citations

    32

    h-index

  5. Journal of the American Chemical Society

    JACS · 36 publications · 2.9K citations

    30

    h-index

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