Concepedia

Binding Pocket Design

Binding Pocket Design is a computational method that specifically enables the de novo creation or optimization of enzyme active sites by tailoring the physicochemical and geometric properties of substrate-binding regions to enhance molecular recognition and catalytic efficiency.

283

Publications

13.6K

Citations

1.8K

Authors

532

Institutions

Publications per year

2017–2026

114

Parents

Publications

283

ACE2 X-Ray Structures Reveal a Large Hinge-bending Motion Important for Inhibitor Binding and Catalysis

Paul Towler, Bart L. Staker, Sridhar G. Prasad et al. · Journal of Biological Chemistry · 2004 · 744 citations · Full text

, , +16

De novo design of luciferases using deep learning

Hsien‐Wei Yeh, Christoffer Norn, Yakov Kipnis et al. · Nature · 2023 · 451 citations · Full text

, , +17

fpocket: online tools for protein ensemble pocket detection and tracking

Peter Schmidtke, Vincent Le Guilloux, Julien Maupetit et al. · Nucleic Acids Research · 2010 · 296 citations · Full text

, , +17

Molecular Mechanism of AMD3100 Antagonism in the CXCR4 Receptor

Mette M. Rosenkilde, Lars‐Ole Gerlach, Janus S. Jakobsen et al. · Journal of Biological Chemistry · 2004 · 239 citations · Full text

, , +14

Discovery of Novel <i>p</i>-Arylthio Cinnamides as Antagonists of Leukocyte Function-Associated Antigen-1/Intracellular Adhesion Molecule-1 Interaction. 1. Identification of an Additional Binding Pocket Based on an Anilino Diaryl Sulfide Lead

Gang Liu, J. T. Link, Zhonghua Pei et al. · Journal of Medicinal Chemistry · 2000 · 218 citations · Full text

, , +17

1–5 of 283

Authors

1.8K

  1. FD
    François Diederich

    ETH Zurich, Switzerland

    8 publications · 292 citations

    8

    h-index

  2. DB
    David Baker

    University of Washington, United States

    6 publications · 662 citations

    6

    h-index

  3. GK
    G. Klebe

    Philipps University of Marburg, Germany

    6 publications · 256 citations

    6

    h-index

  4. CA
    Chris Abell

    University of Cambridge, United Kingdom

    5 publications · 239 citations

    5

    h-index

  5. MA
    Mahmoud Ahmed

    Assiut University, Egypt

    5 publications · 135 citations

    5

    h-index

1–5 of 1.8K

Institutions

532

  1. Chinese Academy of Sciences

    Beijing, China

    12 h-index

    48 publications

    2.1K citations

  2. University of Cambridge

    Cambridge, United Kingdom

    10 h-index

    49 publications

    2.7K citations

  3. Philipps University of Marburg

    Marburg, Germany

    9 h-index

    42 publications

    1.8K citations

  4. Centre National de la Recherche Scientifique

    Paris, France

    8 h-index

    54 publications

    2.3K citations

  5. Jiangnan University

    Wuxi, China

    8 h-index

    43 publications

    1.4K citations

  6. ETH Zurich

    Zurich, Switzerland

    8 h-index

    34 publications

    1.2K citations

  7. The University of Texas Southwestern Medical Center

    Dallas, United States

    7 h-index

    33 publications

    1.3K citations

  8. University of Washington

    Seattle, United States

    7 h-index

    80 publications

    9.2K citations

1–8 of 532

Venues

  1. Journal of Medicinal Chemistry

    27 publications · 1.3K citations

    21

    h-index

  2. Protein Science

    PS · 10 publications · 390 citations

    10

    h-index

  3. Journal of Biological Chemistry

    JBC · 9 publications · 1.4K citations

    9

    h-index

  4. Biochemistry

    9 publications · 486 citations

    9

    h-index

  5. Angewandte Chemie International Edition

    8 publications · 598 citations

    8

    h-index

1–5