Therapeutic targeting of the E3 ubiquitin ligase SKP2 in T-ALL

Activating Mutations of <i>NOTCH1</i> in Human T Cell Acute Lymphoblastic Leukemia

Andrew P. Weng, Adolfo A. Ferrando, Woojoong Lee et al. · Science · 2004 · 2.7K citations

Hematological Malignancy, Human T-all, Activated Notch1 +13

The Immunological Genome Project: networks of gene expression in immune cells

Tracy Heng, Michio W. Painter, Kutlu G. Elpek et al. · Nature Immunology · 2008 · 1.9K citations

Bioinformatics, Immune Cells, Systems Biology +11

SKP2 is required for ubiquitin-mediated degradation of the CDK inhibitor p27

Andrea C. Carrano, Esther Eytan, Avram Hershko et al. · Nature Cell Biology · 1999 · 1.5K citations

Ubiquitin-mediated Degradation, Signal Transduction, Cell Regulation +9

Exclusive development of T cell neoplasms in mice transplanted with bone marrow expressing activated Notch alleles.

Warren S. Pear, Jon C. Aster, Martin Scott et al. · The Journal of Experimental Medicine · 1996 · 711 citations · Full text

Lymphocyte Development, Mixed-phenotype Acute Leukemia, Immunology +22

Targeted disruption of Skp2 results in accumulation of cyclin E and p27Kip1, polyploidy and centrosome overduplication

Kei Nakayama · The EMBO Journal · 2000 · 707 citations · Full text

Genome Instability, Cell Division, Natural Sciences +9